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However, this number is flexible, and your physician will discuss this issue with you. We usually transfer 1 to 2 embryos during each FET cycle. In our laboratory, approximately 60-70 percent of embryos survive cryopreservation and thawing. As with natural cycle FET, embryos are thawed on the morning of the scheduled frozen embryo transfer. Step 2 - Embryo TransferĮmbryo transfer is usually performed on the third to fifth day of progesterone therapy. Depending upon the individual physician’s protocol you may also be treated with oral medications such as methylprednisolone and doxycycline prior to the transfer. If the test is positive, these medications may be continued for several weeks. Estrace® and progesterone are continued until the day of the pregnancy test (usually 12 days after embryo transfer). This may be administered vaginally or as an intramuscular injection. After about 14 days of Estrace®, (your physician may vary the dose or duration of therapy) progesterone is added. We will have you take one pill twice a day for about 14 days. This is a pill containing 2 mg of estradiol, the same hormone produced by the ovaries. A dose of estrogen is usually administered for 14 days, although shorter or longer cycles may be used, Estrace® is the most common form of estrogen we use. It is important that you start estrogen therapy on the first day of your period. Hormone therapy (Estrace® and progesterone).The steps involved in FET with hormone replacement include: FET Cycle If you have never had an endometrial biopsy to evaluate the development of the lining of the uterine cavity or if it has been longer than a year or if you have risk factors for uterine structural abnormalities, we will recommend a uterine cavity evaluation prior to FET, either with a saline infusion sonohystogram, office hysteroscopy or a hysterosalpingogram. In addition, if you have been pregnant, we recommend a repeat uterine measurement before FET.
#Fet pregnancy trial#
We sometimes recommend a trial (practice) cycle before the actual FET cycle so we can perform an endometrial biopsy to ensure that the medication dosages produce the proper development of the uterine lining. Pregnancy rates are equivalent when compared to natural cycle FET. This involves treatment with an oral estrogen medication and progesterone (usually administered vaginally). Frozen Embryo Transfer Using Hormone Replacement: A Step-by-Step Guideįor patients with irregular cycles or ovulation disorders, and for patients who need to plan their therapy around time constraints, we can create an artificial menstrual cycle for FET.